January 27th, 2012
Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2CC17656D, Communication
Hugo L. van Beek, Gonzalo de Gonzalo, Marco W. Fraaije
A thermostable monooxygenase is used as a scaffold to introduce selectivities from other enzymes. This yields biocatalysts with new catalytic properties while maintaining most of the original thermostability.
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January 27th, 2012
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C2OB06792G, Paper
Ajit Kumar Mahapatra, Jagannath Roy, Prithidipa Sahoo, Subhra Kanti Mukhopadhyay, Amarnath Chattopadhyay
A carbazole-thiosemicarbazone-Hg2+ ensemble-based fluorogenic probe for detection of iodide in aqueous media is reported. The practical use of an 'ensemble' was demonstrated by its application to the detection of iodide in the living cells.
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January 27th, 2012
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C2OB06838A, Communication
Sandip A. Pujari, Krishna P. Kaliappan
A stereoselective synthesis of C13-C22 fragment of callystatin A by using an iterative Shimizu non-aldol approach is reported.
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January 27th, 2012
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C2OB06987C, Communication
Guan-Nan Wang, Gabriele Twigg, Terry D. Butters, Siwei Zhang, Liangren Zhang, Li-He Zhang, Xin-Shan Ye
A series of novel N-substituted [varepsilon]-hexonolactams were prepared efficiently using a tandem ring-expansion reaction as the key step. Some synthetic compounds showed better enhancements to N370S mutant [small beta]-glucocerebrosidase activity than NB-DNJ and NN-DNJ.
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January 27th, 2012
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C2OB06681E, Communication
Naganjaneyulu Bodipati, Rama Krishna Peddinti
Highly reactive o-benzoquinone monoimines were chemically generated by the oxidation of o-aminophenols with diacetoxyiodobenzene and successfully trapped with electron-rich vinylic ethers or thioethers to synthesize novel 1,4-benzoxazine derivatives.
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January 27th, 2012
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C2OB06648C, Paper
Angel Martinez-Castaneda, Humberto Rodriguez-Solla, Carmen Concellon, Vicente del Amo
The catalytic system TBD/Al2O3 allows the preparation of thermodynamically-controlled pools of aldols, interconverting through an aldol/retro-aldol sequence, from which moderate levels of diastereoselectivity can emerge.
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January 27th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja211531y
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January 27th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja210180q
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January 27th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja2093647
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January 27th, 2012
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C2OB06641F, Paper
Akihiro Ohkubo, Yudai Nishino, Yu Ito, Hirosuke Tsunoda, Kohji Seio, Mitsuo Sekine
DNA and 2[prime or minute]-OMe-RNA probes containing 5-methyl-2-thiocytidine (m5s2C) residues that can bind selectively and strongly to the corresponding RNA targets containing inosine residues by the significant stacking effect and steric hindrance of the 2-thiocarbonyl group are reported.
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January 27th, 2012
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C2OB06856G, Paper
Xiaoru Wang, Lin Du, Jianlan You, Jarrod B. King, Robert H. Cichewicz
Mutanobactins from an oral-cavity-derived bacterium offer insight into how the human microbiome may afford protection against disease.
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January 27th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja211334k
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January 27th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja211224s
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January 27th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja211010g
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January 27th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja206442c
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January 27th, 2012

Organometallics
DOI: 10.1021/om201055e
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January 27th, 2012
Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2CC16376D, Communication
Na Li, Hui Wang, Mei Xue, Chenyang Chang, Zhenzhen Chen, Linhai Zhuo, Bo Tang
A novel fluorescent nanoprobe with high sensitivity and selectivity for detection and imaging of

in living cells was developed.
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January 27th, 2012
Chem. Commun., 2012, Accepted Manuscript
DOI: 10.1039/C2CC17298D, Communication
Wenbin Lin, Liang Wen, Peng Cheng
This paper reports a novel solvent-induced topological transformation from 2D hinged layers (1) into a 3D porous framework (2) in a single-crystal to single-crystal (SCSC) manner. The structural transformation occurred...
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January 27th, 2012
Chem. Commun., 2012, Accepted Manuscript
DOI: 10.1039/C2CC18132K, Communication
Rajesh G Gonnade, Sekai Iwama, Ryusuke Sugiwake, K Manoj, Hiroki Takahashi, Hirohito Tsue, Rui Tamura
Nearly racemic ketoprofen, which satisfies the requirements for the occurrence of preferential enrichment, was spontaneously resolved into the two enantiomers by simple crystallization under nonequilibrium conditions using high concentrations.
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January 27th, 2012
Org. Biomol. Chem., 2012, Advance Article
DOI: 10.1039/C2OB06808G, Perspective
Pedro Molina, Alberto Tarraga, Francisco Oton
Imidazole derivatives: a range of possibilities in the field of molecular recognition.
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January 27th, 2012
Chem. Commun., 2012, Accepted Manuscript
DOI: 10.1039/C2CC17545B, Communication
Jung-Guk Ha, Jie Song, Jeong-Kyu Lee, Byoung-Ki Cho, Wang-Cheol Zin
In contrast to the known perpendicular ordering of conventional PS-b-PLA thin films, dendritic (PS)2-b-PLA thin films show thickness-dependent parallel orientations, "(10)-on" and "(01)-on", which mostly reside at the bottom and...
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January 27th, 2012
Chem. Commun., 2012, Accepted Manuscript
DOI: 10.1039/C2CC17716A, Communication
Pin-Shen Huang, Chih-Hong Kuo, Chang-Chih Hsieh, Yih-Chern Horng
A simple shape-persistent organic molecular container is capable of selective absorption and storage of I2(g) over water vapor and NO gas even in its amorphous solid state. In addition, the...
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January 27th, 2012
Chem. Commun., 2012, Accepted Manuscript
DOI: 10.1039/C2CC18032D, Communication
Baptiste Plancq, Thierry Ollevier
A highly enantioselective method for the catalytic opening of aromatic meso-epoxides with aniline derivatives was developed. The desired chiral [small beta]-amino alcohols were obtained in mostly good to very good yields...
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January 27th, 2012

Organometallics
DOI: 10.1021/om300045t
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January 27th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja210238g
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January 27th, 2012
Abstract
The oxy-Cope rearrangement of aldol products has been studied both experimentally and theoretically to gain insight into the aspects that are responsible for the exceptional rate and diastereoselectivity of this process. Kinetic studies as well as DFT calculations convincingly show that the activation barrier of this process is mainly dependent on the electronic nature of the oxy-substituent, with electron-withdrawing O-substituents raising this barrier. The diastereoselectivity, however, remains uniformly high for all derivatives investigated and steric factors are proposed to account for the selectivity to a large extent. The poor diastereoselectivity in the case of the anti-aldols was also found in our calculations and it appears to result from unfavorable gauche interactions between the oxy and carboximide groups in the transition state.

Kinetic measurements and DFT calculations on the Cope rearrangement of 3-oxy-1,5-dienes with a syn-aldol structure reveal a close correlation between the activation barrier and the electronic nature of the oxy-substituent, which reflects the exceptional rate and diastereoselectivity of the [3,3]-sigmatropic rearrangement. Steric factors are proposed to account for the diastereoselectivity.
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January 26th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja2111898
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January 26th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja206744z
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January 26th, 2012

Journal of the American Chemical Society
DOI: 10.1021/ja2114344
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January 26th, 2012

Organometallics
DOI: 10.1021/om201068g
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